Cochlear and Vestibular Effects of Combined Intratympanic Gentamicin and Dexamethasone
نویسندگان
چکیده
منابع مشابه
Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla.
Gentamicin is toxic to vestibular hair cells, but its effects on vestibular afferents have not been defined. We treated anesthetized chinchillas with one injection of gentamicin (26.7 mg/ml) into the middle ear and made extracellular recordings from afferents after 5-25 (early) or 90-115 days (late). The relative proportions of regular, intermediate, and irregular afferents did not change after...
متن کاملTRANSLATIONAL PHYSIOLOGY Effects of Intratympanic Gentamicin on Vestibular Afferents and Hair Cells in the Chinchilla
Timo P. Hirvonen, Lloyd B. Minor, Timothy E. Hullar, and John P. Carey Department of Otolaryngology-Head and Neck Surgery, Department of Biomedical Engineering, and Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Otolaryngology, Helsinki University Central Hospital, Helsinki, Finland; and Department of Otolaryngology, Washington Un...
متن کاملVestibular nerve section versus intratympanic gentamicin for Meniere's disease.
OBJECTIVES/HYPOTHESIS Vestibular nerve section and transtympanic gentamicin administration are procedures with proven efficacy in the treatment of vertigo associated with Meniere's disease refractory to medical management. Hearing loss is a known complication of each of these procedures; however, there has not been a report of hearing results of both treatments from a single institution. STUD...
متن کاملIntralabyrinthine Vestibular Schwannoma Responsive to Intratympanic Gentamicin Treatment.
Intralabyrinthine schwannoma (ILS) is a rare benign tumor that affects the ends of cochlear and vestibular nerves. In a majority of the cases, it occurs with unilateral progressive sensorineural hearing loss. Less frequent symptoms include tinnitus, imbalance, vertigo, or fullness. The advent of magnetic resonance imaging allows early diagnosis and enables an appropriate therapeutic protocol. T...
متن کاملSystemic effects of intratympanic dexamethasone therapy
OBJECTIVE The study aimed to assess the possible systemic effects of intratympanic dexamethasone (IT-Dex) on the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, and bone metabolism. DESIGN A prospective cohort study including 30 adult patients of a tertiary referral ENT clinic treated with 9.6 mg IT-Dex over a period of 10 days was carried out. METHODS Effects on plasma and salivar...
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ژورنال
عنوان ژورنال: The Journal of International Advanced Otology
سال: 2017
ISSN: 1308-7649,2148-3817
DOI: 10.5152/iao.2016.2181